PDF] Smad Signal Pathway in BMP-2-induced Osteogenesis-A Mini Review

This article focuses on the influence of BMP-2 on intracellular Smad signal transduction pathways of osteoblasts in osteogenesis. Bone morphogenetic protein-2 (BMP-2) is a multifunctional growth factor, It strongly induces bone formation and belongs to the transforming growth factor-S (TGF-β) superfamily. Recently, recombinant human BMP-2 (rhBMP-2) and rhBMP-7 (also called osteogenic protein-1; OP-1) has become available for clinical applications. This article focuses on the influence of BMP-2 on intracellular Smad signal transduction pathways of osteoblasts in osteogenesis. After BMP-2 binds to the BMP receptor (BMPR) on cell membranes, the BMPR activates receptor-specific Smads (R-Smads) which then associate with the common-mediator Smad (Co-Smad). This complex is translocated into the nucleus and interacts with several transcription factors such as Runx2/Cbfα1, Osx, Dlx5, and Msx2. These molecules mediate the transcription of related genes to induce osteogenesis.

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